The AXIS 221 features an automatic, removable infrared-cut filter, which enables the camera to provide color video when there is sufficient light, and black and white video in dark conditions. It uses a high performance Pentax lens and a progressive scan CCD image sensor that enables moving objects to be presented without distortion. In addition to support for 45 frames per second at all resolutions, the AXIS 221 offers simultaneous Motion JPEG and advanced MPEG-4 video streams to optimize image quality and bandwidth efficiency.

The AXIS 221 also supports a number of advanced features that give the camera increased flexibility and capabilities, including Power over Ethernet, video motion detection, pre- and post-alarm buffer, and inputs/outputs for connecting external devices such as door sensors and relays to activate light or close doors.